2017 Evestra, Inc.

Endometriosis

Evestra is actively pursuing research of viable treatments for endometriosis, and has been awarded a $4.6 million research grant, co-financed by the European Union Regional Development Fund, to support development of our drug candidate EC313 for this indication.

Endometriosis is a common gynaecological disorder first identified in the mid-19th century. It is primarily found in women aged around 25 - 35 years, and occurs in 6 to 10% of the general female population. Endometriosis is defined as the abnormal growth of cells (endometrial glands and stroma) outside of the normal location.

Research suggest that between 20% to 50% of women being treated for infertility have endometriosis, and up to 80% of women with chronic pelvic pain may be affected. The cause of endometriosis is unknown. One theory is that the endometrial tissue is deposited in unusual locations by the backing up of menstrual flow into the Fallopian tubes and the pelvic and abdominal cavity during menstruation. Another theory is that areas lining the pelvic organs possess primitive cells that are able to grow into other forms of tissue, such as endometrial cells.

Most women with endometriosis are a-symptomatic. However, for those who do experience symptoms, the most common are:

 Pelvic pain during or just before menstruation

 infertility

 lower abdominal pain

 diarrhea and/or constipation

 low back pain

 irregular or heavy menstrual bleeding

 blood in the urine

Treatment of endometriosis is dependent upon the specific symptoms; therapies that depend on whether treatment is sought for infertility or for pain. Whether or not family planning is completed can also influence the decision between medical treatment and definitive surgery.

Uterine Fibroids (Leiomyomata)

Uterine fibroids are non-cancerous abnormal growths that develop within or just outside the uterus. Uterine fibroids are very common and as many as 3 out of 4 women have them at some point in life. Usually they are too small to be problematic and can go unnoticed. Research has not yet discovered the cause of uterine fibroids. The body may be predisposed to developing fibroids, but growth seems to depend on estrogen levels in the body. Therefore, they may increase in size with pregnancy and shrink or disappear after menopause.

Medications for uterine fibroids do not eliminate fibroids, but rather shrink them. Treatments include hormones that regulate the menstrual cycle by treating symptoms such as heavy menstrual bleeding and pelvic pressure.

Using hormone replacement therapy containing estrogen after menopause may cause fibroids to continue to grow and cause symptoms.